As a health professional, you need the leading dialysis products, renal pharmaceuticals and critical care solutions.
High-flux dialyzers, backfiltration, and dialysis fluid quality.
Let's work together to find you the tools you need, so you can deliver the best care for patients. Power your practice with our resources. We're here to help support your patients and your thriving practice. Cardiovascular Care. National Cardiovascular Partners.
Because every patient deserves treatment as strong as they are. Investor Relations. FMC Foundation. We strongly recommend that you use a different browser to optimize your viewing experience. Supported browsers include Chrome, Edge, Firefox, and Safari. Published A hollow fiber dialyzer bundle comprises 7—17 x 10 3 semipermeable hollow fibers that allow solute and fluid transfer between blood and dialysate.
Typical fibers have an internal diameter of — microns and wall thickness of 30—40 microns, yielding 1. Fibers may have features, such as undulations, to distribute dialysate flow evenly through the fiber bundle. The fiber bundle is enclosed in an outer housing that forms the dialysate compartment. The header is the space enclosed by the end cap and the polyurethane potting material that holds the hollow fibers and forms a barrier between the blood and dialysate compartments.
Headers channel blood from the dialyzer inlet into the membrane fibers and from the membrane fibers into the dialyzer outlet. The end caps can be removed from some dialyzers. In those cases, an O-ring is used to form a seal between the end cap and the potting material. Blood and dialysate flow in opposite directions countercurrent flow to maximize diffusive solute transfer. Non-synthetic membranes are derived from natural materials such as cotton and are less biocompatible than synthetic membranes.
Biocompatibility can be improved by substituting hydroxyl groups, which reduces the ability of cellulose membranes to activate complement and cause leukopenia. Moieties that have been substituted for cellulose include acetate, diethylaminoethyl DEAEbenzyl, polyethyleneglycolic, and vitamin E.The REVACLEAR dialyzer membrane is designed to remove critical uremic toxins such as urea while retaining important proteins like albumin and other similarly-sized molecules.
At a minimum, mL of saline would be required for priming. This has the potential to save hundreds per patient annually. Baxter's Hemodialysis Delivery Systems are designed to be easy-to-use devices, with app-style interfaces and remote access for clinicians. Baxter offers conventional bloodlines, needles and compression dressings for use in hemodialysis treatment.
Baxter is a global leader in providing saline to healthcare facilities and providers and offers a wide variety of acid and bicarbonate. Rx Only. Comparative effectiveness of dialyzers: a longitudinal, propensity score-matched study of incident hemodialysis patients. Jul 20 IFU N50 ; version ; Date of issue: Skip to main content. View More Products. Hemodialysis Systems Baxter's Hemodialysis Delivery Systems are designed to be easy-to-use devices, with app-style interfaces and remote access for clinicians Learn More about Hemodialysis Systems.
Micromedex Solutions.Inadequacy of dialysis is one of the main causes of death in hemodialysis patients. This study aimed to investigate the dialysis efficacy of low-flux versus high-flux membranes in hemodialysis patients. Forty hemodialysis patients participated in this cross-over clinical trial. Two sessions of low-flux and high-flux membrane dialysis were performed consecutively, in the first and second stage of the trial.
In both stages, blood samples before and after the dialysis were taken and sent to the laboratory for assessment.
Data were analyzed using t test and paired t test. The mean of URR was 0. The high-flux membrane had better dialysis adequacy, so we suggest using high-flux membrane in hemodialysis centers. These people will need hemodialysis HDperitoneal dialysis or kidney transplant to continue their lives 2. There were patients under hemodialysis in Iran in 3. The principle of hemodialysis involves the clearance of solutes across a semi-permeable membrane through diffusion and ultrafiltration mechanisms.
One of the most influential reasons to continue a certain treatment is the degree of its impact on the targeted disease; while, the inadequacy of dialysis has been recognized as a major reason for the mortality rate of the hemodialysis patients If the efficiency of hemodialysis is not adequate, the level of blood toxins and the clinical symptoms of the patient are not controlled, which lead to either an increase in the duration of each dialysis session or the frequency of necessary dialysis per week.
This will consequently increase the mortality and morbidity of the patients and the cost of dialysis 12 There are a number of factors, which influence the adequacy of the dialysis, such as the time of dialysis, the dialysate flow rate, the surface of dialyzer, and the blood flow rate. However, the employments of many of these factors are considered impossible, because they are neither beneficial, nor feasible. For example, increasing the duration of the dialysis over four hours is beyond the patient's tolerance and will increase the cost of dialysis to a large extent.
Furthermore, increasing the dialysate flow rate do not have a significant effect on the adequacy of the dialysis With regard to the available capacity of the dialysis centers across the country and the increasing need for further facilities, it is clinically wise to limit the amount and time of dialysis to an optimal level.
Therefore, reaching to certain level of dialysis adequacy is crucial, and it has led researchers to conduct some projects to obtain this adequacy.
In spite of the emphasis on the employment of high-flux permeable membrane in the available research literature 15 and according to the crucial importance of using these membranes and the emphasis of the National Kidney Association of Iran on the necessity of these permeable membranes 16there are still many wards utilizing low-flux permeable membranes High-flux hemodialysis confers a definite survival advantage in high-risk patients compared with low-flux hemodialysis, according to results from a long-term, prospective trial presented here for the first time.
Manzoni Hospital in Lecco, Italy. He also is professor of nephrology at the University of Brescia and the University of Milan. Among diabetics, the high-flux membrane group had a significantly greater survival advantage over the low-flux membrane group. In contrast, Prof. Locatelli and his colleagues observed no significant differences between the high and low-flux groups in all-cause hospitalizations or hospitalizations for infection or vascular access complications.
Renal function was not significantly better preserved in the high-flux group. Locatelli noted. Thus, they predicted that the MPO finding in the diabetic subgroup would have an important im-pact on ESRD treatment in diabetic patients as this segment of the population continues to grow.High Flux Dialyzer POLYFLUX 170H
As to why high-flux membranes might lead to improved survival, Raymond Vanholder, MD, professor of medicine at the University of Ghent in Belgium, explained that both high and low-flux membranes remove smaller molecules such as urea, but many of these toxins are not that biologically active.
Toxins with a larger molecular weight, however, have been implicated in the high CVD risk seen in hemodialysis patients. Vanholder said. Login Register. Enjoying our content? If you wish to read unlimited content, please log in or register below. Registration is free.
Register for free and gain unlimited access to:. Popular Emailed Recent Loading Please login or register first to view this content. Open Next post in News Close. Log in to continue reading this article.As a health professional, you need the leading dialysis products, renal pharmaceuticals and critical care solutions. Let's work together to find you the tools you need, so you can deliver the best care for patients. Power your practice with our resources.
We're here to help support your patients and your thriving practice. Cardiovascular Care. National Cardiovascular Partners. Because every patient deserves treatment as strong as they are.
Investor Relations. FMC Foundation. We strongly recommend that you use a different browser to optimize your viewing experience. Supported browsers include Chrome, Edge, Firefox, and Safari.
The proven technology of Advanced Fresenius Polysulfone quality, biocompatibility, and performance provide the foundation upon which Optiflux dialyzer technology is built. Our asymmetric membrane structure provides a unique barrier that adsorbs endotoxins. Other advances in fiber and dialyzer technology enable more disruptive flow to improve solute removal. The resulting steeper sieving curve enhances small and middle molecule clearance without increasing albumin loss.
Optiflux high flux ebeam-sterilized dialyzers feature the improved convenience for use in the arterial end upright or arterial inverted position. Additional Resources. Caution: Federal US law restricts these devices to sale by or on the order of a physician.
Note: Read the Instructions for Use for safe and proper use of these devices. For a complete description of hazards, contraindications, side effects and precautions, see full package labeling.Currently, high-flux hemodialysis is the most common mode of dialysis therapy worldwide.
Its steadily increasing use is largely based on the desire to reduce the excessively high morbidity and mortality of end-stage renal disease patients maintained on conventional dialysis low-flux, mostly cellulosic membranes by offering better biocompatibility and enhanced removal of uremic toxins. The major disadvantage of high-flux hemodialysis relates to the use of dialysis fluid, which is commonly not pure and may endanger patients treated with high-flux hemodialysis.
Endotoxin fragments and other bacterial substances derived from bacteriologically contaminated dialysis fluid may, even at bacterial counts or endotoxin concentrations within the limits of accepted standards of dialysis fluid purity, enter from the dialysate into the patient's blood either by convective transfer backfiltration or by movement down the concentration gradient backdiffusion.
Repeated exposure of high-flux hemodialysis patients to backtransport of dialysate contaminants aggravates the uremia-associated inflammatory response syndrome and contributes to long-term morbidity. At present, the only solution to circumvent the risks of backtransport is the use of dry powder cartridges for bicarbonate concentrate and the use of bacteria- and endotoxin-retentive filters for the online production of ultrapure dialysis fluid.
The European Renal Association and a number of national societies in Europe or in Japan strongly recommend the use of ultrapure dialysis for high-flux hemodialysis.The medical device and therapy related information on this website is aimed exclusively at healthcare professionals located within the European Union.
Not all products are cleared or available for sale in all EU countries. Please check the relevant country web site for details.
Optiflux High Flux Single-use Dialyzers
Not all products and services are cleared or available for sale in all EU countries. FX Dialyzers have been used in more than million treatments worldwide. Continuous innovation combined with our commitment to the highest level of quality standards, ensure that our FX Dialyzers portfolio is built to address the individual needs of patients.
All FX Dialyzers have the capacity to remove a broad range of uremic toxins, effectively retain endotoxins, and provide intrinsic biocompatibility. FX classix dialyzers provide high-flux hemodialysis therapy to improve clinical outcomes in patients in comparison to low-flux hemodialysis. The FX paed dialyzer enables high-flux hemodialysis therapy ideally suited for the special needs of pediatric patients.
The removal of uremic toxins and excessive water is the fundamental goal of the hemodialysis treatment.
Several state-of-the-art technologies have been combined to create the distinctive functional properties of the FX Dialyzers. Together they make a difference in terms of beneficial patient outcomes, smooth handling and cost savings potential. The blue header with its laterally placed blood inlet port is designed to reduce the risk of kinked bloodlines, aiming at smooth handling and allowing healthcare professionals to focus on what really matters — the best care for patients.
The FX Dialyzers are developed for system compatibility, perfectly fitting into automatic priming procedures with low rinsing volumes and short preparation times.
In addition, there is no need to turn any FX Dialyzer during the priming procedure. Moreover, the FX Dialyzers have a removable label that can easily be attached to patient records, allowing for quick documentation. Precise nanoscale modulation of pore size, structure and distribution favors minimal resistance to solute transfer across the membrane and contributes to improved clearances compared to macro-design membranes.
It prevents the channelling of the dialysis fluid and ensures that each fiber within the bundle is perfectly surrounded by the dialysis fluid. The optimized header design of the FX Dialyzers ensures a homogenous blood flow path. Its geometry allows a spiral distribution of blood in the dialyzer header, preventing low velocity stagnation zones and resulting in an enhanced performance. Rinsing with hot steam assures a gentle sterilization — without the need for chemicals or irradiation, which may lead to increased cytotoxic 14 and carcinogenic residuals.
The INLINE steam sterilization process allows for the efficient use of resources during preparation as well as a reduction of costs, since only mL rinsing volume is required. The process. Cytotoxicity is minimal after steam sterilization, whereas it increases with gamma irradiation. Changes of the material properties can be observed after sterilization with gamma irradiation, while the material remains intact in this respect when using steam sterilization.
Increased losses of albumin during dialysis sessions have been observed with gamma sterilized dialyzers which were stored for a longer time.
The advanced housing material of any FX Dialyzer is made of environmentally friendly and lightweight polypropylene. We asked artists to interpret the benefits of the FX Dialyzers in their own way.
The color blue of the FX Dialyzer caps became their inspiration point.
High-Flux Hemodialysis Has Advantages
Nephrology ; — E et al. The typical number of treatments in most clinics is approximately 10, per year; this results in about 1, kg less waste being produced annually with FX classix 80 when used on FME CorDiax machine.
Source: publications. FX CorDiax dialyzers. English Deutsch. Back to Homepage. Accepted and Confirmed.
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